Complement activation by polysaccharide of lipopolysaccharide: an important virulence determinant of salmonellae
نویسندگان
چکیده
منابع مشابه
Complement activation by polysaccharide of lipopolysaccharide: an important virulence determinant of salmonellae.
Salmonellae with differences only in the O-antigenic polysaccharide of their lipopolysaccharide were previously shown to differentially activate complement via the alternative pathway, causing them to be ingested at different rates by the mouse macrophage-like cell line J774. We now show that this mechanism could explain the different virulence of these strains in vivo. Mouse peritoneal macroph...
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15 صفحه اولComplement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide.
Fulminant meningococcal sepsis has been termed the prototypical lipopolysaccharide (LPS)-mediated gram-negative septic shock. Systemic inflammation by activated complement and cytokines is important in the pathogenesis of this disease. We investigated the involvement of meningococcal LPS in complement activation, complement-dependent inflammatory effects, and cytokine or chemokine production. W...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1983
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.41.2.563-569.1983